Omics · study · 2026
ZIC2 affects oral squamous cell carcinoma stemness by regulating glycerophosphocholine metabolism via LYPLA2
Listed in NCBI GEO
Oral squamous cell carcinoma (OSCC) is a common malignant tumor of the head and neck.
Description
Early-stage OSCC is mainly treated with surgery; for advanced cases, multidisciplinary treatments including surgery combined with adjuvant radiotherapy and chemotherapy are the main approaches. In our previous studies, we found through experiments and bioinformatics analysis that ZIC2 is highly expressed in OSCC and is associated with poor prognosis in patients.
Subsequently, we constructed stable knockdown control (sh-NC) and experimental (sh-ZIC2) cell lines of ZIC2 using lentivirus, and conducted high throughput sequencing analysis to detect downstream differentially expressed genes, and performed enrichment analysis on the differentially expressed genes to identify related pathways.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE304nnn/GSE304366 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE304366 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1301123 ncbi.nlm.nih.gov/bioproject/PRJNA1301123 ↗
project · from NCBI GEO
- PubMed 41856987 pubmed.ncbi.nlm.nih.gov/41856987 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 65% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE304366 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |