Omics · study · 2026
ALKBH5 acts as a regulator for hair follicle telogen to anagen transition
Listed in NCBI GEO
Hair cycle transitions play a pivotal role in sustaining hair growth, particularly the switch from telogen to anagen.
Description
During this process, hair follicle stem cells (HFSCs) are regulated by a complex and dynamic niche of signals that drive the cell state from quiescence to activation. However, how HFSCs adjust their state to respond to these signals remains unclear.
Here, we show that Alkbh5 expression is downregulated during late telogen, and its deletion promotes HFSC activation and proliferation, accelerating the telogen–anagen transition in mice. In vitro, ALKBH5-deficient HFSCs display enhanced proliferation under 3D culture. Loss of ALKBH5 increases the m6A methylation of Mcam, which is subsequently recognized and bound by YTHDF1, thereby stabilizing Mcam mRNA.
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Mcam expression increases as Alkbh5 decreases during late telogen, and Mcam knockdown impairs HFSC proliferation, potentially through reduced Wnt responsiveness. Furthermore, Mettl3 is also involved in maintaining hair cycle progression. We conclude that ALKBH5, a facilitator for hair cycle transition, dynamically regulates Mcam expression mediated by m6A methylation, and that proper HFSC activation potentially requires a balanced m6A regulatory mechanism involving both ALKBH5 and METTL3.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE310nnn/GSE310777 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE310777 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1367059 ncbi.nlm.nih.gov/bioproject/PRJNA1367059 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus · Other
- From keywords
- Life Sciences
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE310777 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |