Excel · study · 2026
MOLECULAR LANDSCAPE OF ORAL EPITHELIAL DYSPLASIA: GENE EXPRESSION PROFILING IN CHILEAN PATIENTS
Listed in NCBI GEO
ABSTRACTObjectives: To determine the relative gene expression levels and to describe and compare RNA sequence variations in samples from Chilean patients diagnosed with Oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC).
Description
Methodology: Transcriptome sequencing was performed on pooled samples of OED and compared with OSCC and healthy oral mucosa tissue samples. Subsequently, a variation analysis of the transcriptome was conducted, along with functional classification of the most enriched signaling pathways.
Results: Dysregulated genes were found in both OED and OSCC compared to the control groups. The most overexpressed genes were KRTAP5-4, LCE3B, MYH2, DDX3Y, KDM5D, and MYH2, while the most repressed genes were TYRP1, HS3ST6, SNORA20, KRT76, TGM7, and SOX21 in OED and OSCC, respectively. A large proportion of the identified variants were single nucleotide polymorphisms (SNPs).
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Based on frameshift effects, missense mutations were the most common. The most enriched signaling pathways in OED were the Hippo, NOTCH, and TGF-beta pathways; in OSCC, the NGR2, TGF-beta, and PI3K pathways. Conclusion: This study revealed distinct gene expression patterns and variants associated with OED and OSCC in Chilean patients, contributing to a better understanding of their molecular landscape.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE307nnn/GSE307821 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307821 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1327370 ncbi.nlm.nih.gov/bioproject/PRJNA1327370 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE307821 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |