Omics · study · 2026
Cabozantinib inhibits the growth of lenvatinib-resistant hepatoma cells restoring FTCD expression
Listed in NCBI GEO
The present study aims to determine whether cabozantinib can suppress tumor growth of lenvatinib-resistant HCC cell lines in vitro and in vivo.
Description
We established a lenvatinib-resistant Hep3B cell line (Hep3B-LR) and evaluated the inhibitory effect of cabozantinib on the growth of Hep3B-LR cells. Hep3B-LR exhibited approximately 20 times greater IC50 for lenvatinib than the wild type.Cabozantinib suppressed tumor growth of Hep3B-LR in vitro and in vivo.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE259nnn/GSE259287 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE259287 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1080586 ncbi.nlm.nih.gov/bioproject/PRJNA1080586 ↗
project · from NCBI GEO
- PubMed 38815631 pubmed.ncbi.nlm.nih.gov/38815631 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Non-coding RNA profiling by array
- From keywords
- Life Sciences
- Inferred from text
- Cancer 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE259287 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:non-coding-rna-profiling-by-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |