Effects of LXR intervention on transcriptome expression in the injury area of mice with spinal cord injury

Reverse cholesterol transport (RCT) is the major pathway responsible for lipid efflux, yet its functional dynamics and regulatory imbalance after SCI remain poorly understood. This study aims to characterize the temporal expression patterns and cellular localization of key RCT components (ABCA1, ABCG1, and APOE) after SCI, and to evaluate whether activation of the LXR/RXR pathway by the agonist AZ876 can modulate RCT function, reduce foam cell accumulation, and improve neurological recovery.