Omics · study · 2026
Transcriptomic analysis of the effects of Poly I:C on islet cells in NOD mice
Listed in NCBI GEO
The relationship of autoimmune type 1 diabetes (T1D) and natural killer (NK) cells remains unclear.
Description
Poly inosine:cytidine (PolyI:C) is a double-stranded RNA mimic that activates an anti-viral response through TLR3 signaling and leads to activation of NK cells. Here we administered PolyI:C to female NOD mice in order to understand how NK cell activation changes the islet microenvironment by altering transcriptomes of islet cells.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE345nnn/GSE345972 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE345972 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1522478 ncbi.nlm.nih.gov/bioproject/PRJNA1522478 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE345972 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |