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Excel · study · 2026

Evaluation of clofazimine treatment on functional gene transcription in hepatocellular carcinoma cells

Listed in NCBI GEO

Clofazimine (CFZ) is an orally administered anti-mycobacterial drug that demonstrates a broad spectrum of activity against mycobacterial infections, including leprosy and tuberculosis.

Description

CFZ also possesses anti-inflammatory and anti-tumor properties by disrupting DNA replication and inhibiting the production of IL2. Currently, this compound has been utilized in research related to drug-resistant cancer treatment, and has gained increasing recognition for its potential to enhance cancer treatment in recent years.

Considering the benefits of CFZ in clinical settings, it presents itself as a promising candidate for combination drug therapy aimed at hepatocellular carcinoma through the regulation of functional gene transcription. Herein, we primarily examine the role of CFZ treatment throughout the functional gene transcription process in hepatocellular carcinoma cells.

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From keywords
Life Sciences
Inferred from text
Cancer 75%
Provenance · 1 source records, 8 field assertions
SourceKeyLast seenRaw
NCBI GEOGSE32760014 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[disease].local:disease:cancerenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[field].local:field:life-sciencesmapping · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencingsource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[organism].NCBITaxon:9606source · NCBI GEOconnector:ncbi_geo@1.0.0/taxon
descriptionsource · NCBI GEOconnector:ncbi_geo@1.0.0/summary
publication_datesource · NCBI GEOconnector:ncbi_geo@1.0.0
titlesource · NCBI GEOconnector:ncbi_geo@1.0.0/title