Omics · study · 2026
Integrated multi-omic analysis of GATA2 and GATA3 unveil their master regulatory roles on the trophoblast fate [RNA-seq]
Listed in NCBI GEO
The commitment and differentiation of human placental progenitor cells are crucial for a successful pregnancy, but the underlying regulatory mechanism remains poorly understood.
Description
Here we identified the transcription factor (TF), GATA2 and GATA3, exerting genetic redundancy, for cell fate decision of trophoblast cells. Using human expanded potential stem cells (hEPSC) as a model, we demonstrated that double knockout (DKO) of GATA2&3 failed for differentiation of trophoblast.
Exogenous inducible over-expression GATA2&3 in DKO cells rescued trophoblast defects, in terms of gene expression.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE266nnn/GSE266534 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE266534 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1107530 ncbi.nlm.nih.gov/bioproject/PRJNA1107530 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE266534 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |