Omics · study · 2026
Predicting relevant microglia-associated cell-cell communication pathways in Alzheimer’s disease: a role for SPP1
Listed in NCBI GEO
Microglia play a key role in the pathophysiology of Alzheimer’s Disease (AD) and their increased heterogeneity likely affects disease progression.
Description
We previously identified distinct microglial signatures that were enriched in AD donors and associated with amyloid and tau, respectively. Here we analyzed cell-cell communication pathways that might be relevant to AD pathophysiology.
We generated a snRNAseq dataset from postmortem control and AD cases and analyzed alterations in cell-cell communications. One signaling pathway perturbed in AD cases involved SPP1, and while this pathway was also present in control samples, microglia-microglia SPP1 signaling was restricted to AD donors. Further analyses within microglia-microglia signaling predict AD-specific induction of GAS6-AXL signaling (from inflammatory and ribosomal microglia), and SPP1-ITGAV/ITGB5 signaling (from disease-associated and inflammatory microglia, among others).
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Together, these findings might in part explain the increased microglia phagocytic profile described in AD.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE335nnn/GSE335667 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE335667 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1479072 ncbi.nlm.nih.gov/bioproject/PRJNA1479072 ↗
project · from NCBI GEO
- PubMed 42552722 pubmed.ncbi.nlm.nih.gov/42552722 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE335667 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |