The differentially expressed proteins in WT liver tissues and FetA KO liver tissues of NIAAA model mice

In this study, we found that FetA knockout or knockdown significantly reduced hepatic lipid droplet accumulation, oxidative stress, and inflammation in AFLD mice. FetA deletion leads to increase of autophagy flux and results in decreased TLR4 protein levels, subsequently inhibiting the NF-kB signaling pathway and the formation of pro-inflammatory M1 macrophages and then reducing the release of inflammatory cytokines. In short, our study indicates that inhibition of FetA could help prevent or reverse the progression of AFLD, and the FetA-TLR4 axis may be a target for AFLD drug development.