Table · dataset · 2026
Mesenchymal stromal cells ameliorate experimental PSC alongside gut microbiota remodeling and enhanced vitamin B6 metabolism
Listed in ZivaHub and HKU DataHub and figshare and Loughborough Research Repository and UP Research Data Repository — shown once because both records carry DOI 10.6084/m9.figshare.32447160.v2
<p dir="ltr">Primary sclerosing cholangitis (PSC) is a progressive cholangiopathy tightly linked to gut microbiota dysregulation via the gut-liver axis.
Description
While mesenchymal stromal cell (MSC) therapy holds promise for PSC, whether and how the gut microbiota mediates its efficacy remain unknown. Using Mdr2⁻/⁻ mice, we found that human placenta‑derived MSCs significantly alleviated PSC symptoms, reducing serum liver enzymes, inflammatory cytokines, and histopathological scores.
Antibiotic‑mediated gut microbiota depletion partially abrogated these protective effects, indicating a microbiota-dependent mechanism. 16S rRNA sequencing revealed that MSC treatment reshaped gut microbial composition, notably enriching the SCFA‑producing genus g_UBA1819 while depleting the disease‑associated genus g_Alistipes. Functional predictions indicated downregulated lipopolysaccharide biosynthesis and upregulated biotin biosynthesis.
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Untargeted metabolomics identified reduced fecal levels of 4‑Hydroxy‑3‑(3‑methyl‑2‑butenyl)acetophenone and 4‑Hydroxy‑3‑methylbenzaldehyde, with pathway analysis highlighting vitamin B6 metabolism as a key module linked to MSC therapy. Integrative correlation analyses of differential metabolites, gut microbiota, and liver enzymes, combined with in vivo validation, confirmed that microbiota-derived vitamin B6 mediates the hepatoprotective effects of MSCs in PSC.
Collectively, our data demonstrate that MSCs exert therapeutic effects in PSC by reprogramming the gut microbiota and subsequently elevating vitamin B6 levels, establishing a novel “MSC–microbiota–vitamin B6” regulatory axis. These findings provide mechanistic insights and potential microbial biomarkers for MSC‑based therapy in PSC.</p>
Links
Where it is published
- DOI doi.org/10.6084/m9.figshare.32447160.v2 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Astronomy & Astrophysics · Chemistry · Chemistry · Computer Science & AI · Computer Science & AI · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Economics & Finance · Economics & Finance · Engineering · Engineering · Engineering · Humanities · Humanities · Humanities · Life Sciences · Life Sciences · Life Sciences · Life Sciences · Life Sciences · Materials Science · Mathematics & Statistics · Medical bacteriology · Medical bacteriology · Medical bacteriology · Medical bacteriology · Medical bacteriology · Medical biochemistry - amino acids and metabolites · Medical biochemistry - amino acids and metabolites · Medical biochemistry - amino acids and metabolites · Medical biochemistry - amino acids and metabolites · Medical biochemistry - amino acids and metabolites · Medicine & Health · Medicine & Health · Medicine & Health · Medicine & Health · Medicine & Health · Ocean & Atmospheric Science · Psychology & Behavioral Science · Social Science · Social Science · Social Science
- Inferred from text
- Disease 75% · Sequencing 75%
Provenance · 5 source records, 52 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32447160 | 7 d ago | JSON v1 |
| HKU DataHub | oai:figshare.com:article/32447160 | 6 d ago | JSON v1 |
| figshare | oai:figshare.com:article/32447160 | 6 d ago | JSON v1 |
| Loughborough Research Repository | oai:figshare.com:article/32447160 | 5 d ago | JSON v1 |
| UP Research Data Repository | oai:figshare.com:article/32447160 | 5 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:field:320501 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Medical biochemistry - amino acids and metabolites'] |
| concepts[field].anzsrc:field:320501 | mapping · researchdata up ac za | vocabulary-mapper@1.0.0 | keywords['Medical biochemistry - amino acids and metabolites'] |
| concepts[field].anzsrc:field:320501 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Medical biochemistry - amino acids and metabolites'] |
| concepts[field].anzsrc:field:320501 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Medical biochemistry - amino acids and metabolites'] |
| concepts[field].anzsrc:field:320501 | mapping · datahub hku hk | vocabulary-mapper@1.0.0 | keywords['Medical biochemistry - amino acids and metabolites'] |
| concepts[field].anzsrc:field:320701 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Medical bacteriology'] |
| concepts[field].anzsrc:field:320701 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Medical bacteriology'] |
| concepts[field].anzsrc:field:320701 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Medical bacteriology'] |
| concepts[field].anzsrc:field:320701 | mapping · datahub hku hk | vocabulary-mapper@1.0.0 | keywords['Medical bacteriology'] |
| concepts[field].anzsrc:field:320701 | mapping · researchdata up ac za | vocabulary-mapper@1.0.0 | keywords['Medical bacteriology'] |
| concepts[field].local:field:astronomy | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:engineering | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:engineering | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:engineering | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:humanities | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:humanities | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:humanities | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:materials-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:mathematics-statistics | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:ocean-atmospheric | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:psychology-behavioral | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:social-science | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[modality].local:modality:sequencing | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/rights |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |