Omics · study · 2026
Effect of SMALS-329 treatment on gene expression in ACHN renal carcinoma cells
Listed in NCBI GEO
LKB1 is a tumor suppressor kinase whose inactivation is associated with poor prognosis and therapeutic resistance in multiple cancer types.
Description
To investigate the transcriptional effects of pharmacological LKB1 activation with SMALS-329, we performed RNA sequencing of ACHN renal carcinoma cells following treatment with 8 mM SMALS-329 for 24 hours. Gene set enrichment analysis identified an enrichment of genes involved in cell adhesion/mobility (11 genes) and cell polarity (6 genes) as the key downregulated group of genes.
Additionally, we noted significant regulation, both up and down, of several inflammatory mediators and components of the unfolded protein response (UPR). These findings are consistent with the known effects of LKB1, namely the regulation of metabolism, inflammation, cell adhesion/mobility and cell polarity and the UPR.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE341nnn/GSE341378 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE341378 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1501451 ncbi.nlm.nih.gov/bioproject/PRJNA1501451 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE341378 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |