Omics · study · 2026
Transcriptomic analysis of punicic acid-treated ovarian cancer and normal epithelial cell lines
Listed in NCBI GEO
Ovarian cancer is a highly lethal gynecological malignancy with limited effective therapeutic options.
Description
In this study, we investigated the effects of punicic acid (PunA) on ovarian cancer and normal epithelial cells. RNA-seq analysis was performed on ovarian cancer cell lines (HEYA8 and A2780) and normal epithelial cell lines (P201 and E7) to characterize transcriptional changes induced by PunA treatment.
PunA preferentially reduced cancer cell viability, with comparatively less effect on normal cells. Transcriptomic profiling revealed differential regulation of genes associated with oxidative stress, lipid metabolism, mitochondrial function, and ferroptosis-related pathways. These data provide insight into the molecular mechanisms underlying PunA-mediated anticancer effects.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327747 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327747 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1452667 ncbi.nlm.nih.gov/bioproject/PRJNA1452667 ↗
project · from NCBI GEO
- PubMed 42121893 pubmed.ncbi.nlm.nih.gov/42121893 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE327747 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |