Omics · study · 2026
RNA-seq Analysis of the 5-HT2B Receptor Agonist BW723C86 on PBMC
Listed in NCBI GEO
This study employed RNA sequencing (RNA-seq) to investigate the effects of the 5-HT2B receptor (HTR2B) agonist BW723C86 on phagocytic function in human peripheral blood mononuclear cells (PBMCs).
Description
Primary human PBMCs were treated with BW723C86 or vehicle control（DMSO）, and transcriptomic changes related to phagocytosis were analyzed. RNA-seq data revealed significant modulation of genes involved in phagocytic pathways following HTR2B activation.
Gene Set Enrichment Analysis (GSEA) demonstrated significantly upregulates phagocytosis-associated gens,including CD63,CTSA and CTSD. These findings provide molecular evidence that HTR2B activation by BW723C86 regulates phagocytic capacity in human PBMCs, suggesting a potential role for the receptor in modulating innate immune functions .
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328813 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328813 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1456587 ncbi.nlm.nih.gov/bioproject/PRJNA1456587 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE328813 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |