Omics · study · 2026
Transcriptome of TEX cell line following two CDK8 inhibitors treatment
Listed in NCBI GEO
TEX cells maintaining functional and phenotypic hierarchy of AML, with leukemia stem cells (LSC) characteristics (PMID: 16094415) was treated with two CDK8 inhibitors (CDK8i) RVU120 (Ryvu) and CCT251921 (Merck), to delineate molecular changes upon CDK8i time course (3h, 24h and 72 hours).
Description
There were 984, 4357 and 4257 common differentially expressed genes (FDR <0.05) for both inhibitors with correlation coefficients of 0.82, 0.95 and 0.95, respectively, for 3h, 24h and 72h time points.
The dataset generation was supported by the National Science Center grant (2018/30/E/NZ2/00801).
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE309nnn/GSE309991 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE309991 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1364880 ncbi.nlm.nih.gov/bioproject/PRJNA1364880 ↗
project · from NCBI GEO
- PubMed 42587822 pubmed.ncbi.nlm.nih.gov/42587822 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE309991 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |