Omics · study · 2026
Developmental regulation of progenitor aging shapes long-term intestinal homeostasis in Drosophila
Listed in NCBI GEO
This study investigates whether adult tissue aging trajectories are established early during development by genetically modulating cellular aging pathways in Drosophila larval adult midgut progenitors (AMPs)—the precursors to adult intestinal stem cells.
Description
Bulk transcriptomic analysis reveals that accelerating larval AMP aging via immune overactivation (Toll/Imd) or elevated reactive oxygen species (ND42 knockdown) causes long-term adult consequences, including disrupted progenitor architecture, genomic instability, epithelial barrier failure, and skewed lineage allocation towards enteroendocrine cells.
Conversely, decelerating larval AMP aging via Foxo or Atg8a overexpression protects adult intestinal barrier integrity, demonstrating that early-life developmental programming in AMPs tightly dictates the long-term trajectory and homeostasis of the adult gut.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE337nnn/GSE337803 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE337803 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1491100 ncbi.nlm.nih.gov/bioproject/PRJNA1491100 ↗
project · from NCBI GEO
Topics
- Stated by source
- Drosophila melanogaster · Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE337803 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:7227 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |