Supplementary file 1_Interocular symmetry of retinal and choroidal OCT parameters in precapillary pulmonary hypertension: a brief research report.docx

Purpose<p>To assess interocular symmetry of retinal and choroidal optical coherence tomography (OCT)-derived parameters in patients with precapillary pulmonary hypertension (PH) and healthy controls, and to evaluate the implications of symmetry for oculomics-based biomarker development.</p>Methods<p>In this cross-sectional study, 29 patients with precapillary PH and 37 age- and sex-matched healthy controls underwent standardized spectral-domain OCT.

Retinal and choroidal thicknesses, volumes and binarized choroidal biomarkers were quantified using validated protocols. Interocular agreement was assessed with intraclass correlation coefficients (ICC), Spearman's rank correlation (ρ), and paired testing with false discovery rate control.</p>Results<p>Median interocular agreement was good but parameter-specific (ICC 0.76 in precapillary PH and 0.78 in controls). In PH, agreement was highest for choroidal metrics.