Omics · study · 2026
Comprehensive Transcriptomic Analysis of DLD1 Colon Cancer Cells Overexpressing TRMT6 and TRMT61A Genes [RNA-seq]
Listed in NCBI GEO
This study investigates the transcriptomic changes in DLD1 colon cancer cells upon overexpression of TRMT6 and TRMT61A genes, with a focus on identifying downstream genes associated with tumor cell senescence.
Description
We performed RNA-seq, tRNA m1A-MeRIP-seq, and ribo-seq on DLD1 cells overexpressing TRMT6 and TRMT61A, as well as control cells, each with two biological replicates. The integrated analysis of these sequencing data aims to elucidate the molecular mechanisms underlying the regulation of tumor cell senescence by TRMT6 and TRMT61A.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE290nnn/GSE290123 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE290123 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1225140 ncbi.nlm.nih.gov/bioproject/PRJNA1225140 ↗
project · from NCBI GEO
- PubMed 41504222 pubmed.ncbi.nlm.nih.gov/41504222 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · RNA sequencing 65% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE290123 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |