Laurocapram inhibits Salmonella infection via dual mechanisms

In response to the escalating challenge of antibiotic resistance, this study aims to explore novel antimicrobial agents, and we demonstrated that Laurocapram inhibits intracellular replication of Salmonella; to investigate its mechanism, we conducted RNA sequencing (RNA-seq) on murine macrophage-like RAW264.7 cells under four conditions: untreated control, Laurocapram treatment alone, Salmonella Typhimurium infection, and S. Typhimurium infection with concurrent Laurocapram treatment, with the goal of identifying key host genes and cellular pathways manipulated by the pathogen during infection and elucidating how Laurocapram counteracts Salmonella infection by modulating these targets.