Omics · study · 2026
Effect of overexpression of Lipoprotein lipase (LPL) on MS-1 endothelial cells
Listed in NCBI GEO
Immune regulation of endothelial cell is esstential for efficient anti-tumor T cell immunity.We here report LPL lipoprotein lipase as a key regulator of endothelial immune response.
Description
The overexpression of LPL results in enhanced antigen presentation on endothelial cell, which in turns enhance T cell homing.Moreover, LPL also enhance the sensitivity of EC to IFN-g exposure, with elevated percentage of apoptotic cells. Taken together, our data provide a molecular framework of the effect of LPL on endothelial cells.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE289nnn/GSE289731 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE289731 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1223910 ncbi.nlm.nih.gov/bioproject/PRJNA1223910 ↗
project · from NCBI GEO
- PubMed 42474324 pubmed.ncbi.nlm.nih.gov/42474324 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE289731 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |