Hippocampal interferon-response, unfolded-protein-response and synaptic transcriptional signatures in RORgt-transgenic mice

We performed bulk RNA sequencing of bilateral hippocampi from untreated 10-week-old male RORgt-transgenic mice and wild-type littermates (n = 3 per genotype) to characterize gene-level and gene-set transcriptional differences. RNA-seq identified a small set of FDR-significant genes and gene-set enrichment patterns involving interferon responses, unfolded protein response, and synaptic/calcineurin-related processes.

The dataset is intended to support transparent reanalysis of the hippocampal transcriptomic phenotype associated with the RORgt-transgenic genotype.