Omics · study · 2026
Systemic administration of CD28-deprived in vitro-induced regulatory T cell attenuates pathological remodeling caused by pressure overload-induced cardiac fibrosis
Listed in NCBI GEO
In heart failure, myocardial fibrosis driven by immune-mediated inflammation contributes to progressive cardiac dysfunction.
Description
We investigated the therapeutic efficacy of CD28-deprived in vitro–induced regulatory T cells (iTreg), a stable Treg subset, in a murine model of pressure overload–induced heart failure. CD28-deprived iTreg were intravenously administered one week after transverse aortic constriction (TAC).
Treated mice showed improved cardiac function, reduced ventricular fibrosis, and Treg localization in the heart. Transcriptomic analysis revealed downregulation of profibrotic and proinflammatory pathways, including TNF-α/NF-κB and TGF-β signaling. These findings suggest that systemic delivery of CD28-deprived iTreg effectively modulates the inflammatory microenvironment and suppresses cardiac remodeling, offering a promising immunomodulatory strategy for treating heart failure.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE300nnn/GSE300131 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE300131 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1279091 ncbi.nlm.nih.gov/bioproject/PRJNA1279091 ↗
project · from NCBI GEO
- PubMed 41798793 pubmed.ncbi.nlm.nih.gov/41798793 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cardiac remodeling 75% · Heart 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE300131 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[anatomy].local:anatomy:heart | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[disease].local:disease:cardiac-remodeling | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |