Severe hyperchylomicronemia sensitizes the heart to pathological remodeling: evidence from GPIHBP1 deficient mice

GPIHBP1 deficiency disrupts intravascular triglyceride-rich lipoprotein hydrolysis and results in severe hyperchylomicronemia. To investigate the molecular changes associated with chronic triglyceride-rich lipoprotein accumulation in the heart, total RNA was isolated from cardiac tissues and subjected to high-throughput transcriptome sequencing.

These data provide a resource for characterizing gene expression alterations and biological pathways associated with cardiac metabolic remodeling, mitochondrial dysfunction, and heart failure susceptibility in the setting of severe hypertriglyceridemia.