Omics · study · 2026
Cross-tissue single-cell atlas including central and peripheral immune tissues in experimental autoimmune myasthenia gravis (EAMG)
Listed in NCBI GEO
Myasthenia gravis (MG) is an autoimmune disease with an incompletely understood mechanism and limited treatment options.
Description
MG is a systemic autoimmune disease, complex abnormal humoral and cellular immune responses play a crucial role in the pathogenesis of MG. The pathological changes involve not just individual immune tissues, but also complex interactions among multiple organs and systems.
However, the majority of previous studies focused on abnormalities in peripheral blood and the thymus. With the development of high-throughput technology, several studies have unbiasedly revealed abnormal numbers and function of immune cells by single-cell RNA sequencing and, cytometry-of-time-flight/mass cytometry (CyTOF), indicated pivotal role of aberrant changes in innate immune cells, including monocytes and natural killer cell (NK), in the pathogenesis of MG.
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Nevertheless, these innate immune cells reside not only in blood, but also widely within the central and peripheral immune organ including bone marrow, thymus, spleen, and lymph nodes. But it is particularly difficult to collect these samples from patients and healthy control, hindering the comprehensive understanding of pathological mechanisms of MG. In the present study, single-cell sequencing technology was used to construct a cross-tissue single-cell atlas including bone marrow, thymus, spleen, lymph and whole blood in experimental autoimmune myasthenia gravis (EAMG) model
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE306nnn/GSE306764 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE306764 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1312068 ncbi.nlm.nih.gov/bioproject/PRJNA1312068 ↗
project · from NCBI GEO
- PubMed 41709234 pubmed.ncbi.nlm.nih.gov/41709234 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Rattus norvegicus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 75%
Provenance · 1 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE306764 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10116 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |