Omics · study · 2026
The purinergic receptor P2rx7 mediated ATP sensing is required to prevent bone aging by directing mitochondrial fitness of MSCs
Listed in NCBI GEO
Bone aging contributes to osteoporosis and impaired bone formation, mechanisms intricately linked to alterations in mesenchymal stem cells (MSCs) that include a metabolic decline whose precise mechanisms remain elusive.
Description
In this study, P2rx7 was identified as a key regulator of mitochondrial fitness in bone marrow MSCs during the bone aging process. To validate the role of P2rx7 in bone metabolism and aging, we deleted P2rx7 by using P2rx7 knockout mice and the mice demonstrated premature and exacerbated bone aging.
What we want to explore is how P2rx7 knockout affects the genome changes of bone cells.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE268nnn/GSE268046 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE268046 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1114093 ncbi.nlm.nih.gov/bioproject/PRJNA1114093 ↗
project · from NCBI GEO
- PubMed 40518112 pubmed.ncbi.nlm.nih.gov/40518112 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE268046 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |