Base transcriptomes of seven, untreated patient-derived MPNST cell lines, two of which are PRC2-WT and five PRC2-LoF

Inactivating mutations in the genes that encode for subunits of the Polycomb Repressive Complex 2 (PRC2) are common genetic events that lead to loss of H3K27me3 and subsequently high grade tumors with worse clinical outcomes for patients with Neurofibromatosis type-1. We profiled transcriptomes of seven patient-derived MPNST cell lines of varying PRC2 status (WT vs LoF) with the intention to detect gene expression differences that might be driven by loss of PRC2 function.