Data · dataset · 2026
Cardiovascular disease in patients with cancer or amyloidosis
Listed in ZivaHub and Deakin Research Online and DMU Figshare and UCL Research Data Repository — shown once because both records carry DOI 10.17034/32633640.v1
This thesis comprises of two parts which report three component studies each involving cardio-oncology and transthyretin cardiac amyloidosis (ATTR-CA). <br><br>The association between CVD and cancer is increasingly recognized.
Description
To further investigate CVD in patients with cancer and improve gaps in knowledge, we investigated the frequency and temporal relationships of CVD. We reported temporal trends of all CVD within 1 year of chemotherapy and risk factor association pre-chemotherapy and post-chemotherapy.
We developed network-based methodology for unbiased cardiac risk stratification for cancer patients with CTRCD. Using this method, we identified 4 subgroups that had the most distinct survival rate among the overall cohort. In terms of CVD, the most common risk factor was found to be atrial fibrillation (AF) and this was further investigated diagnosis of AF relative to cancer diagnosis according to age and the associations between AF timing, CHA2DS2-VASc score, cancer therapeutics and mortality in selected oncology patients. <br><br>The second section of this thesis focuses on ATTR-CA, which is associated with CVD and is an evolving entity.
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ATTR-CA is increasingly recognized as a cause of heart failure in older patients. Cardiac scintigraphy with technetium-99m-pyrophosphate (99mTc-PyP) labelled bone-seeking tracers is used to non-invasively make the diagnosis of ATTR-CA based on the presence of ventricular uptake. Atrial uptake (AU) on 99mTc-PyP is currently not clinically reported.
We investigated AU and the relative interaction with atrial fibrillation, ATTR-CA, and clinical outcomes. Using von Kossa staining (a phosphate binding dye) within histopathological samples of patients that confirm the presence of micro-calcifications with atrial and ventricular tissue. For the next chapter, I focused on aortic stenosis (AS) and investigated AV calcification in patients with and without ATTR-CA using propensity matching to compare. <br><br>In this thesis, I report a wide variety of findings and observations of CVD in cardio-oncology and ATTR-CA. <br><br><i>Thesis is embargoed until 31 July 2028.</i>
Links
Where it is published
- DOI doi.org/10.17034/32633640.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Medicine & Health · Medicine & Health · Medicine & Health · Medicine & Health
- Inferred from text
- Cancer 75% · Cardiovascular disease 75% · Disease 75% · Heart 75% · Oncology and carcinogenesis 72%
Provenance · 4 source records, 18 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32633640 | 11 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32633640 | 11 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32633640 | 11 d ago | JSON v1 |
| UCL Research Data Repository | oai:figshare.com:article/32633640 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[anatomy].local:anatomy:heart | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[disease].local:disease:cancer | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[disease].local:disease:cardiovascular-disease | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[disease].local:disease:disease | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:3211 | enrichment · zivahub uct ac za | taxonomy-embedding@1.1.0 | title+keywords+description (72%) |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |