Omics · study · 2026
Intestinal T-bet+ plasmablasts mediate epithelial barrier dysfunction and inflammatory bowel disease
Listed in NCBI GEO
Crohn’s disease (CD) and ulcerative colitis (UC) are complex diseases characterized by epithelial barrier dysfunction and intestinal inflammation.
Description
While B cells have historically received limited attention in inflammatory bowel disease (IBD) research, recent studies have highlighted the accumulation of IgG+ cells in inflamed tissues. In this study, we confirmed the enrichment of IgG⁺ antibody-secreting cells in resected lesions from CD patients and identified a distinct CD11c⁺ population localized exclusively to lesional tissue.
These cells resembled age-associated B cells (ABCs), a proinflammatory population implicated in other autoimmune diseases.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE331nnn/GSE331003 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE331003 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1466483 ncbi.nlm.nih.gov/bioproject/PRJNA1466483 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens · Other
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE331003 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |