Omics · study · 2026
A single-cell RNA sequencing dataset of kidney and peripheral blood mononuclear cells from Dahl salt-sensitive rats under high and low salt diets
Listed in NCBI GEO
Hypertension is a major global health burden, with high dietary sodium intake being a key environmental risk factor.
Description
The Dahl salt-sensitive (SS) rat is a well-established model for studying salt-sensitive hypertension and renal damage. To facilitate research into the cellular mechanisms of salt-sensitivity, we generated a single-cell RNA sequencing (scRNA-seq) dataset from the kidney and peripheral blood mononuclear cells (PBMCs) of Dahl SS rats.
Male rats were fed either a high-salt (4% NaCl) or low-salt (0.4% NaCl) diet for three weeks. We profiled high-quality cells from kidney tissue and from PBMCs. This dataset captures the cellular diversity of these tissues, including immune, epithelial, and endothelial cell populations, under different dietary conditions.
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This resource provides a foundation for investigating how high sodium intake influences cellular composition, gene expression, and cell-cell communication at single-cell resolution. As the Dahl SS rat remains one of the most widely used models for hypertension research, this dataset offers a valuable reference for exploring cell-type-specific responses to salt and generating hypotheses for future mechanistic studies.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE345nnn/GSE345203 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE345203 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1516669 ncbi.nlm.nih.gov/bioproject/PRJNA1516669 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Rattus norvegicus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE345203 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10116 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |