Omics · study · 2026
Whole-Transcriptome RNA-Seq of Kidney Tissue from Patients in the Alport Spectrum
Listed in NCBI GEO
Alport syndrome encompasses a spectrum of glomerular basement membrane disorders associated with pathogenic variants in COL4A3, COL4A4, and COL4A5.
Description
In this study, bulk whole-transcriptome RNA sequencing was performed on kidney biopsy tissue from 93 samples exhibiting GBM alterations consistent with the Alport spectrum. The dataset includes transcript abundance, alternative splicing, and exon usage information for collagen IV–related and other GBM-associated genes.
Publicly available normal kidney transcriptome data from the GTEx project were used as an external reference for selected downstream analyses but are not included in this GEO submission. This dataset provides a resource for investigating transcriptomic variation and splicing complexity in kidney tissue from individuals with Alport spectrum disorders and related nephropathies.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE318nnn/GSE318857 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE318857 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1420726 ncbi.nlm.nih.gov/bioproject/PRJNA1420726 ↗
project · from NCBI GEO
- PubMed 42614610 pubmed.ncbi.nlm.nih.gov/42614610 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE318857 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |