Data · dataset · 2026
Supplementary Figure 4 from The H63D Polymorphism in the <i>HFE</i> Gene Promotes Aggressive Disease Phenotypes in Pancreatic Ductal Adenocarcinoma
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.1158/1078-0432.34041293
<p>:(A) Representative Opal multiplex immunofluorescence staining of FFPE PDAC tissues from WT (non-carrier) and H63D cases showing TWIST1 (red) and Ki67 (green), highlighting their co-localization within tumor cells.
Description
Images were acquired at 20× magnification; scale bar: 200um. (B) Representative Western blot analysis of c-MYC protein expression in FFPE PDAC tissues from <i>HFE</i> wild-type (WT), H63D heterozygous, and H63D homozygous carriers (upper panel).
Lower panel: densitometric quantification of c-MYC band intensity normalized to GAPDH. Although c-MYC levels showed a progressive increase across genotypes, differences did not reach statistical significance (one-way ANOVA, p = 0.50). (C) Phase contrast representative images of SA β-galactosidase activity.
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The blue color represents the positivity to the staining. Magnification 20x. Scale bar 100 um.
(D) Detection of apoptotic cells obtained by PE- Annexin V flow cytometry assay. Values are expressed as median ±SD. *p.value <0,05; **p.value <0,01 by Mann Whitney test. (E) Representative Opal multiplex immunofluorescence staining of FFPE PDAC tissues from WT (non-carrier) and H63D cases showing β2-microglobulin (red) and HFE (green), highlighting their co-localization.
Images were acquired at 20× magnification; scale bar: 200um</p>
Links
Where it is published
- DOI doi.org/10.1158/1078-0432.34041293 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Cancer · Cancer · Cancer · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Life Sciences · Life Sciences · Life Sciences · Medicine & Health · Medicine & Health · Medicine & Health
- Inferred from text
- Disease 75% · Image 65% · Oncology and carcinogenesis 72%
Provenance · 3 source records, 19 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/34041293 | 11 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/34041293 | 11 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/34041293 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[disease].local:disease:cancer | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[disease].local:disease:cancer | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[disease].local:disease:cancer | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[disease].local:disease:disease | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:3211 | enrichment · zivahub uct ac za | taxonomy-embedding@1.1.0 | title+keywords+description (72%) |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[modality].local:modality:image | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (65%) |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |