Omics · study · 2026
A lineage shared core gene expression network specific to human infants, links human evolution to ASD in oligodendrocytes and Parkinsons disease in neurons
Listed in NCBI GEO
Human-specific faculties of neural development at the postnatal stage are largely unknown, as evolutionary comparisons have either relied on adult material, immature cell culture proxies, or comparisons with more distant species.
Description
To address this, we performed snRNAseq (10x Genomics) on rare human, chimpanzee, and rhesus macaque prefrontal cortex (PFC) infant samples. This study represents the first to include infant chimpanzee samples in such evolutionary comparisons, providing novel insight into human-specific neural development and its susceptibility to neural disease.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294786 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294786 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1251600 ncbi.nlm.nih.gov/bioproject/PRJNA1251600 ↗
project · from NCBI GEO
- PubMed 42234754 pubmed.ncbi.nlm.nih.gov/42234754 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE294786 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |