Omics · study · 2026
The mutational landscape of STING-induced immunity
Listed in NCBI GEO
Stimulator of interferon genes (STING) is an evolutionary conserved immune signalling protein with key roles in host defence, cancer, senescence and inflammation.STING activation leads to type I interferon (IFN), NF-κB pathway and non-canonical autophagy responses.
Description
Despite its central role in immunity and relevance as therapeutic target, the sequence elements that govern STING (in)activation in cells remain poorly understood.
Here we developed a massively parallel assay to systematically chart the sequence-function landscape of STING. Profiling thousands of single amino-acid variants, we reconstructed structural and functional determinants that moderate or enable, respectively, STING’s immunostimulatory capacity and its ability to translate ligand recognition into cellular effector responses. Cryo-electron microscopy structures of distinct STING hyperactive variants revealed novel regulatory principles dictating conformational transition from inactive to signalling-competent states of STING.
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Collectively, these findings define the molecular principles that tune STING activity and chart the full landscape of its functional potential across immune contexts.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE330nnn/GSE330097 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE330097 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1462716 ncbi.nlm.nih.gov/bioproject/PRJNA1462716 ↗
project · from NCBI GEO
- PubMed 42343134 pubmed.ncbi.nlm.nih.gov/42343134 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · Microscopy 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE330097 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:microscopy | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |