Network pharmacological analysis of nobiletin in anti-breast cancer

1. Acquisition of the target of nobiletin: using "nobiletin" as the keyword, the targets were obtained in the SEA database (sea.bkslab.org/, set P<0.05, species as HUMAN) and the TargetNet database (http: / / targetnet.scbdd.com/, AUC 0.7 or higher installed, the fingerprint type ECFP4), Swiss Target Prediction database (swisstargetprediction.ch/, Set the Probability> 0 and the CTD database (ctdbase.org /) for retrieval.

After merging and de-duplication of the obtained targets, the potential targets of nobiletin were finally obtained.2. Acquisition of breast cancer targets: With "breast cancer" as the key word, In Genecards database (genecards.org/) (the set Relevance Score > 10), OMIM database (omim.org/search/advanced/geneMap), providing database (db.idrblab.net/ttd/) and DisGeNet database (disg The search was conducted on enet.com/), the obtained targets were combined and duplicated, and finally the targets related to breast cancer disease were obtained3.