Data · dataset · 2025
Integrated Transcriptomic Analysis Revealed Lymphatic-mediated Immune Dynamics after Myocardial Infarction
Listed in ScienceDB
This dataset contains single-cell RNA sequencing (scRNA-seq) gene expression matrices derived from mouse hearts after myocardial infarction (MI).
Description
The study aims to investigate the role of lymphatic endothelial cell (LEC)-specific Icam1 in regulating immune responses and cardiac remodeling.Cardiac ventricular tissues were collected from both control and Icam1 conditional knockout (Icam1cko) mice at 3, 7, 21, and 42 days post-MI.
Non-cardiomyocytes were isolated and subjected to scRNA-seq. The count matrices provided here include gene expression profiles for individual cells across all time points and genotypes.
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.j00139.00250 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
- Inferred from text
- Cardiac remodeling 75% · Heart 65% · Myocardial infarction 75% · RNA sequencing 75% · Sequencing 75% · Single-cell RNA sequencing 75%
Provenance · 1 source records, 16 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.j00139.00250 | 5 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[anatomy].local:anatomy:heart | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[disease].local:disease:cardiac-remodeling | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[disease].local:disease:myocardial-infarction | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[modality].local:modality:rna-seq | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/rights |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |