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Omics · study · 2026

RNA Sequencing of the Impact of CXCR3 receptor modulation on activated T cells function

Listed in NCBI GEO

First, we used human PBMCs to establish a T - cell activation model, and activated T cells with the polyclonal stimulants PMA and Ionomycin.

Description

Before activating the PBMCs, we pretreated them with the CXCR3 antagonist AMG 487 and agonist VUF 11222. Then, through transcriptome sequencing, we explored the effects of these two chemicals on activated T cells, analyzing differentially expressed genes and associated signaling pathway changes to evaluate whether chemical regulation of the CXCR3 receptor impacts T cell function.

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Expression profiling by high throughput sequencing · Homo sapiens
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Life Sciences
Inferred from text
RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
SourceKeyLast seenRaw
NCBI GEOGSE30162213 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[field].local:field:life-sciencesmapping · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencingsource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[modality].local:modality:rna-seqenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[modality].local:modality:sequencingenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[organism].NCBITaxon:9606source · NCBI GEOconnector:ncbi_geo@1.0.0/taxon
descriptionsource · NCBI GEOconnector:ncbi_geo@1.0.0/summary
publication_datesource · NCBI GEOconnector:ncbi_geo@1.0.0
titlesource · NCBI GEOconnector:ncbi_geo@1.0.0/title