Omics · study · 2026
Effect of GnRH administration on gene expression of obese mice neural stem cells
Listed in NCBI GEO
To explore the underlying mechanism of recognitive enhancement after GnRH supplementation, we used an obese mouse model that was given high fat diet (HFD) for three months.
Description
Treatment with saline or GnRH was given via implanted osmotic pumps for one month. Treatment was started after two months of feeding.
Our results revealed that GnRH significantly promoted hippocampal neurogenesis in obese mice via the GnRH receptor GnRHR, indicating the essential role of GnRH and its targets in hippocampal neural stem cells.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE275nnn/GSE275318 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE275318 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1150248 ncbi.nlm.nih.gov/bioproject/PRJNA1150248 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE275318 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |