Data · dataset · 2026
Mosaic Nanoparticles Based on Porcine Ferritin Elicit Potent Protective Immunity in Pigs against Multiple Lineages of Serotype O FMDV
Listed in ScienceDB
The serotypes and subtypes of foot-and-mouth disease virus (FMDV) are highly diverse, making the research and development of broad-spectrum and high-efficiency foot-and-mouth disease (FMD) vaccines increasingly urgent.
Description
In this study, we designed and constructed two mosaic nanoparticle proteins by fusing porcine Ferritin (pFt) and Lumazine Synthase (LS) protein as nano-scaffolds with B-cell epitopes (VP1 G-H loop) from multi-lineage strains of serotype O FMDV and a conserved 3D T-cell epitope using the prokaryotic expression system.
The results of mouse experiments confirmed that compared with 3D-LS-mGHs, 3D-pFt-mGHs can induce stronger specific protective immune responses in mice. Meanwhile, the homologous pFt nano-scaffold can reduce the host's immune rejection effect against vector proteins, and effectively improve the immune efficacy of vaccines and the safety of biological applications. Subsequently, the immune protective effect of the 3D-pFt-mGHs in pigs was evaluated.
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The results demonstrated that the 3D-pFt-mGHs not only induced potent cross-protective effects against multi-lineage strains of serotype O FMDV in pigs but also triggered a potential Th2-type cellular immune response, achieving complete protection of pigs against serotype O FMDV infection. Collectively, this developed 3D-pFt-mGHs mosaic nanoparticles possesses great application potential for broad-spectrum prevention and control of serotype O FMDV.
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.40597 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Medicine & Health · Social Science
- Inferred from text
- Disease 75% · Medical biotechnology 70%
Provenance · 1 source records, 13 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.40597 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:3206 | enrichment · scidb cn | taxonomy-embedding@1.0.0 | title+keywords+description (70%) |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/rights |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |