Morphological and Functional Diversity of Spatially Resolved Vestibular Ganglion Neuron Cell Types

Compared with other sensory systems, our understanding of the molecular heterogeneity of VGNs and its contribution to the diverse functions of the vestibular system remains limited. Using single-cell and spatial transcriptomics, we defined five transcriptionally distinct VGN cell types with discrete spatial distributions across the ganglion.

The proper localization of VGN cell types requires intact hair cell mechanotransduction machinery. These VGN cell types demonstrate organ-specific innervation patterns, target defined zones within each organ, and form characteristic synaptic endings. To probe their functional roles, we generated genetic tools that selectively label each VGN cell type.