Transcriptomic Analysis of Potency Associated Genes in Hematopoietic Stem and Progenitor Cells

Functionally potent HSCs/HPCs from bone marrow, mobilized peripheral blood, or umbilical cord blood drive recovery of the hematopoietic system following transplantation.

Improving initial characterization of the engraftment potential of donor grafts and recovery time will lead to improved patient outcomes, particularly in the case of umbilical cord blood transplantation, which is limited by low total numbers of cells. However, we still lack a complete understanding of the molecular programs that regulate potency, which is the ability of cells to home to and engraft in a hematopoietic niche, then self-renew and differentiate driving multi-lineage repopulation.