Omics · study · 2026
Characterization of a Human Cutaneous Squamous Cell Carcinoma Xenograft Mouse Model
Listed in NCBI GEO
To study the biology of immune cell biology (e.g. human cutaneous gamma delta T cell) in human skin tumours, an in vivo SCC xenograft mouse model was established.
Description
To closely resemble the human skin microenvironment, human tumour cells were introduced into an engineered human skin on the back of NSG mice. Transcriptome analysis of bulk-RNAseq data generated from biopsies of the xenograft model as well as human skin and tumour was conducted to test which features of the model resemble the situation in humans.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE326nnn/GSE326341 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326341 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1445120 ncbi.nlm.nih.gov/bioproject/PRJNA1445120 ↗
project · from NCBI GEO
- PubMed 42341104 pubmed.ncbi.nlm.nih.gov/42341104 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE326341 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |