Text · study · 2026
CRISPRi lncRNA depletion screen in acute myeloid leukemia cell lines
Listed in NCBI GEO
To identify long non-coding RNAs (lncRNAs) essential for proliferation and survival of acute myeloid leukemia (AML) cells, we performed a genome-wide CRISPRi depletion screen using a custom CRISPRi lncRNA library.
Description
Six AML cell lines (K562, THP-1, ML-2, SKNO-1, M07e, NOMO-1) were screened with two biological replicates each. sgRNA representation was measured at baseline (Day 0) and after 18 population doublings. Screen hits were identified using the MAGeCK MLE algorithm with copy number variation correction.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE326nnn/GSE326775 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326775 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1446899 ncbi.nlm.nih.gov/bioproject/PRJNA1446899 ↗
project · from NCBI GEO
- PubMed 42380666 pubmed.ncbi.nlm.nih.gov/42380666 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Other
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE326775 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |