Omics · study · 2026
Compartment specific mitochondrial unfolded protein response
Listed in NCBI GEO
Alzheimer’s disease lacks effective disease‑modifying treatments partly because early, compartment‑specific mitochondrial stress responses in microglia remain poorly defined.
Description
Our findings show that APP expression and targeted activation of UPRmt-MM or UPRmt-IMS produce distinct transcriptional signatures—ranging from immune activation and impaired oxidative phosphorylation to disrupted mitochondrial ribosome integrity—highlighting mitochondrial compartmentalization as a key driver of AD pathogenesis and a potential therapeutic target.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE315nnn/GSE315336 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE315336 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1395659 ncbi.nlm.nih.gov/bioproject/PRJNA1395659 ↗
project · from NCBI GEO
- PubMed 42694256 pubmed.ncbi.nlm.nih.gov/42694256 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE315336 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |