Omics · study · 2026
Loss of CSDE1 Function Enhances mRNA Stability of Interleukin-6 and Promotes Malignant Transformation in Endometrial Cancer Cells.
Listed in NCBI GEO
CSDE1 (cold shock domain-containing protein E1) is an RNA-binding protein that plays a critical role in regulating mRNA stability and translation.
Description
Previous studies suggest that CSDE1 is downregulated or mutated in various cancers, including endometrial cancer (EC), but its exact role in tumor progression remains unclear. In this study, we demonstrate that the loss of CSDE1 function promotes malignant transformation in EC cells by enhancing the stability of interleukin-6 (IL-6) mRNA.
Using data from The Cancer Genome Atlas (TCGA), we show that CSDE1 is frequently mutated and significantly reduced in EC tissues. CSDE1 depletion in EC cell lines using CRISPR-Cas9-mediated knockout (KO) significantly increases cell proliferation, migration, and invasion, and induced epithelial-to-mesenchymal transition (EMT). Transcriptomic analysis reveals robust mRNA upregulation of IL-6, a cytokine known to drive inflammation and tumor progression.
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We show that CSDE1 directly interacts with IL-6 mRNA and CSDE1 loss stabilizes IL-6 mRNA. Functionally, silencing IL-6 or inhibiting its signaling with siltuximab reverse the malignant phenotypes induced by CSDE1 knockout. These findings identify CSDE1 as a tumor suppressor in EC and uncover a novel CSDE1–IL-6 regulatory axis that drives tumor progression, positioning IL-6 as a potential therapeutic target in CSDE1-deficient EC.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE310nnn/GSE310724 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE310724 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1366990 ncbi.nlm.nih.gov/bioproject/PRJNA1366990 ↗
project · from NCBI GEO
- PubMed 42177550 pubmed.ncbi.nlm.nih.gov/42177550 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE310724 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |