Genome-wide analysis of histone H3K18 lactylation in a kainic acid-induced epilepsy model

In this study, we aimed to investigate whether lactate-associated histone modification contributes to epileptogenesis and to define its downstream transcriptional targets. Using a kainic acid (KA)-induced temporal lobe epilepsy model, we examined genome-wide chromatin occupancy of histone H3 lysine 18 lactylation (H3K18la) in control and epileptic mouse hippocampal tissues by ChIP-seq.

The objective of this study was to characterize H3K18la-associated epigenetic changes during epileptogenesis and to identify candidate genes and pathways regulated by this histone mark. These data provide a genome-wide resource for understanding how glycolysis-related histone lactylation is involved in transcriptional regulation during seizure development.