Text · study · 2026
Identification of a set of transcriptional regulators involved in the temporal regulation of neuron subtype differentiation
Listed in NCBI GEO
The sequential generation of various types of neurons and glia from neural stem /progenitor cells (NSPCs) during development is a major part to build complex central nervous system.
Description
COUP-TFI/II (NR2F1/2) are critical factors for the temporal specification of NSPCs including neurogenesis-to-gliogenesis switch. MicroRNA miR-17 has also been shown to regulate acquisition of gliogenic competence by NSPCs downstream of COUP-TFs.
We tried to identify candidate genes that are involved in the temporal change of the potency of NSPCs for the sequential generation of different neuron subtypes but not acquisition of gliogenic competence downstream of COUP-TFs.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE309nnn/GSE309874 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE309874 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1363929 ncbi.nlm.nih.gov/bioproject/PRJNA1363929 ↗
project · from NCBI GEO
- PubMed 42000103 pubmed.ncbi.nlm.nih.gov/42000103 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by array · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE309874 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |