Omics · study · 2026
Temporal RNA-seq analysis of host transcriptional remodeling during lytic murine gammaherpesvirus 68 (MHV-68) infection
Listed in NCBI GEO
Bulk RNA sequencing was performed to characterize host transcriptional changes during lytic murine gammaherpesvirus 68 (MHV-68) infection.
Description
NIH 3T3 cells were mock- or MHV-68-infected (multiplicity of infection of 5) and harvested at 4, 8, 12, and 24 hours post-infection, representing immediate early through very late stages of lytic replication. Differential expression analysis revealed extensive and time-dependent remodeling of host gene expression, including immune, metabolic, chromatin-associated, and transcriptional pathways.
This dataset provides a temporal framework for understanding host responses during productive lytic gammaherpesvirus infection.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE314nnn/GSE314414 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE314414 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1390887 ncbi.nlm.nih.gov/bioproject/PRJNA1390887 ↗
project · from NCBI GEO
- PubMed 42198775 pubmed.ncbi.nlm.nih.gov/42198775 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE314414 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |