Excel · study · 2026
SS-31 protects against paraquat-induced lung injury and fibrosis via inhibition of the MAPK signal pathway
Listed in NCBI GEO
Aims: To explore the therapeutic effect of SS-31 on lung injury and lung fibrosis caused by paraquat (PQ).
Description
Methods
In vivo experiments involved the intraperitoneal injection of PQ solution into C57BL/6 mice to induce lung injury and fibrosis. Subsequently, SS-31 solution was administered intraperitoneally on a daily basis to investigate its protective effects against PQ-induced lung injury and fibrosis. In vitro use of PQ caused inflammatory responses in A549 cell line, and the therapeutic effects of SS-31 were explored by treatment with different concentrations of SS-31 in A549.
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The SS-31 pathway of action was explored and validated by RNA sequencing. Results: In vivo, SS-31 reduced PQ-induced mortality, acute lung injury, lung fibrosis and apoptosis in mice. The same results were obtained iin vitro experiments.
SS-31 was found to inhibit the MAPK pathway by RNA sequencing. The mechanism was further validated by verifying MAPK pathway proteins and applying MAPK pathway agonists. Innovation and Conclusion: In vivo and in vitro experiments demonstrated that SS-31 reduces lung injury and fibrosis induced by PQ.
It works through inhibition of the MAPK signaling pathway.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE261nnn/GSE261616 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE261616 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1088117 ncbi.nlm.nih.gov/bioproject/PRJNA1088117 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE261616 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |