Omics · study · 2026
Urolithin A attenuates inflammation and enhances barrier integrity in an experimental NEC-in-a-Dish model
Listed in NCBI GEO
Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease in preterm infants, characterized by exaggerated inflammation and poorly understood pathogenesis.
Description
Aryl hydrocarbon receptor (AhR) signaling has been shown to reduce intestinal inflammation in colitis models. In these models, a microbial-derived AhR ligand, Urolithin A (UroA), has demonstrated anti-inflammatory properties and improved gut barrier function.
We hypothesize that UroA attenuates inflammation and enhances epithelial barrier integrity in an in vitro NEC-in-a-Dish model.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE312nnn/GSE312490 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE312490 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1374058 ncbi.nlm.nih.gov/bioproject/PRJNA1374058 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE312490 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |