Omics · study · 2026
Transcriptomic and miRNA profiling of colorectal adenocarcinoma and healthy mucosa
Listed in NCBI GEO
The ACTB gene, traditionally considered a reference gene, exhibits transcriptional instability in colorectal cancer tissues.
Description
The aim of this study was to evaluate the transcriptomic profile of colorectal adenocarcinoma, with a specific focus on structural genes and their regulatory networks within the tumor microenvironment. We conducted high-throughput mRNA profiling (Affymetrix GeneChip Human Gene 2.0 ST) of colorectal tumor tissues and healthy colonic mucosa.
In parallel, a pilot microRNA screening (Affymetrix GeneChip miRNA 4.0) was performed on a subset of samples to uncover potential tumor-specific rewiring of regulatory networks involving ACTB and tumor-suppressive miRNAs.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE336nnn/GSE336767 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE336767 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1482554 ncbi.nlm.nih.gov/bioproject/PRJNA1482554 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by array · Homo sapiens · Non-coding RNA profiling by array
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE336767 | 7 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:non-coding-rna-profiling-by-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |